Liver abscess due to S.typhi is an extremely rare occurrence and is associated with high mortality. We describe a 40-year-old female patient with PUO in whom ultrasound revealed a liver abscess and culture of ultrasound guided liver aspirate yielded S.typhi. The Widal testwas positivewith very high titers. No pre-existing liver pathology could be found. Ciprofloxacin therapy resulted in complete recovery.We report the clinical, radiological and microbiological features of this rare condition.