Serum lipids and apoprotein b levels in neonates and their correlation with maternal lipid profile & placental weight

ABSTRACT

To establish correlation if any between neonatal lipid profile and Apoprotein B levels and maternal nutritional markers (lipids,
Apo-B and placental weight).Correlation of lipid profile of newborns with markers of maternal nutrition. Settings: Department of Pediatrics, Department of Obstetrics & Gynecology. New born  abies and their mothers. Methods: The cord blood samples at birth and peripheral blood  amples at oneweek of agewere taken from500 neonates and their mothers and tested for  lipid parameters viz. cholesterol, LDL, HDL, VLDL,Chylomicrons, LDL-C, HDL-C, and VLDL-C. The weight of mother’s placentawas also taken upto the nearest 10 grams. The mean  maternal lipid values and Apo-B levels were significantly higher compared to their newborns. No significant correlation could be made between maternal lipids and neonatal plasma lipids except that infant’s HDLC approached closest to maternal HDLC levels. Amongst the “preterms”, babies born to mothers with acceptable cholesterol levels (less than 240 mg/dl) had favorable lipid profile compared to those born to mothers with  unacceptably high cholesterol levels (more than 240 mg/dl). No such difference was seen amongst the term new borns. It was also noted that as the placental weight increases, the cholesterol, LDL (low density lipoprotein) and Apo-B (Apoprotein B) rise correspondingly. This correlation was maintained even at one week of age. The strength of correlation  between placentalweight and mean lipid values highlights the importance of such a study, where  placental weight and maternal lipid values have been taken asmarkers ofmaternal nutrition.

ABSTRACT

Looking at the effects of insulin deficiency on carbohydrate and lipid metabolism, diabetes mellitus is now being called more a disease of lipid metabolism than carbohydrate metabolism. A cross-sectional study was conducted during March 2005 to March 2006 to study the glycosylated haemoglobin (HbA1c) and lipid levels in normal adults and with type -2 diabetes mellitus and its
relation to glycaemic control. Comparison of  lipid levels was made between group of diabetic patients and the normals. The lipid fractions i.e.Total cholesterol, triglycerides, and low-density lipoprotein levels of poorly controlled diabetic (HbA1c > 8 %), were respectively higher (p<0.001), (p<0.01) and (p<0.001) than those of the control group. Later the lipid levels decreased drastically with glycaemic control (p>0.05, p>0.05 and p<0.05 respectively). Increased levels of low-density lipoprotein may be a contributory factor to the high risk of atherosclerosis induced coronary artery disease observed in diabetes mellitus patients. Reduction of blood glucose levels is likely to reduce low density lipoprotein levels and the  risk of complication, with the lowest risk being in
those with glycosylated hemoglobin values in the normal range i.e. less than 8.0%.