ABSTRACT

The prevalence of hypertension and its complications are on the rise in the urban population, possibly related to their sedentary lifestyle, stressful job and altered eating habits. Most of the hypertensive population are under diagnosed, untreated, and have inadequate awareness about the disease and associated risk factors. In this study, records of 117 hypertensive patients who underwent treadmill test were analyzed to see the effect of three commonly used antihypertensive drugs and the occurrence of associated risk factors . The patients on Angiotensin converting enzyme inhibitors/Angiotensin receptor blockers (ACEI/ARB), Beta Blockers (BB) and Calcium Channel Blockers (CCB) are expected to have a good control over their BP during treadmill test. But in our study, the rise in mean maximum exercise systolic and diastolic blood pressure of ACEI/ARB groupwere found to be statistically significant when compared to Beta blockers and Calcium channel blockers group.There is also occurrence of significant associated risk factors among the three groups. Hence the combination of the above antihypertensive drugs with Beta Blockers may adequately control exercise induced hypertension .The control of associated risk factors like obesity, Diabetes, Dyslipidemia is also very important to prevent cardiovascular morbidity and mortality.

ABSTRACT

The prevalence of hypertension is increasing at an alarming rate worldwide. Hypertension is now considered as ‘metabolic syndrome’. High blood pressure affects many systems of the body and can alter various biochemical parameters in essential hypertensive patients. Objective: The present studywas undertaken to study effects of calcium channel blockers (CCBs) on different biochemical parameters in essential hypertensive patients.
Materials and Methods: 21 females and 18 males with mild to moderate hypertensionwere enrolled in the age group of 25- 80 yrs.
All 39 patients received mono drug therapy with calcium channel blockers, for six months. Levels of total cholesterol(TC), LDL, HDL cholesterol, triglycerides, uric acid, fasting blood sugar and serum electrolytes sodium, potassium and calcium were measured at pretreatment and at the end of six months drug therapy. Statistical significance of difference was calculated by using students paired ‘t’ test.
Results: At the end of six months there was significant decrease in total cholesterol (TC), serum uric acid level and significant increase in HDL cholesterol.
Conclusion: Calcium channel blockers are well tolerated when administered as mono therapy. These findings suggest that calcium channel blockers may be an attractive option for treatment of essential hypertension and for improving cardio vascular (CV) risk profile and also in patients having gout.